Published: Fri, January 12, 2018
Medicine | By Brett Sutton

Popular painkiller can alter male hormone balance, research finds

Popular painkiller can alter male hormone balance, research finds

They revealed that levels of luteinising hormones, which trigger testosterone production, increased during the study. CNN reports that while it has been known for quite some time that ibuprofen use can cause birth defects in male babies, the full effects of ibuprofen on male fertility hadn't been studied in depth until now.

Dr David Kristensen, of Copenhagen University, said: "Through a clinical trial with young men exposed to ibuprofen, we show that the analgesic resulted in the clinical condition named "compensated hypogonadism" - a condition prevalent among elderly men and associated with reproductive and physical disorders".

The problem ranges worldwide: The World Health Organization says that one of every four couples spends at least five years unsuccessfully trying to get pregnant.

These treatments may help those suffering from fertility issues after long-term ibuprofen use, but the best way to address issues related to that NSAID is to just stop taking it.

"These compounds are good painkillers, but a certain amount of people in society use them without thinking of them as proper medicines", he added.

Ibuprofen is "especially interesting" because of its increasing use in the general population - and by elite athletes - for aches, pains, fever and arthritis.


Jegou agreed that more study is needed to answer a number of questions, including how low doses of ibuprofen affect male hormones and whether long-term effects are reversible, CNN reported.

Jégou said, in these men these hormonal imbalances would be reversible as it was given for a short period of time.

Again, it's important to emphasize this was a really small study that required two weeks of constant ibuprofen use before there was any indication that something was out of the ordinary. The experimental group received ibuprofen twice a day for a total of six weeks and was tested for hormone levels at two and six weeks. The highlighted cardiac and hormonal disruption risks point toward the need to be cautious with such medications, and anyone who is concerned should talk to their doctor about it before taking the medication.

The new study has given major information about lower fertility in males. These are the findings of a new study published on Monday in the journal "Proceedings of the National Academy of Sciences". Physicians advise taking this medicine with caution, no longer than 10 days in a row.

"But no direct effect on fertility was shown, but the results of this initial study suggest that it warrants further investigation".

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